Research suggests that LSD, known for its psychedelic properties, may hold promise in alleviating pain. While mechanisms are not fully understood, LSD likely modulates serotonin receptors and neural networks involved in pain processing. Clinical evidence, though limited, hints at its efficacy in chronic pain, migraines, and end-of-life distress. Challenges such as legal barriers and safety concerns necessitate further research. If proven effective and safe, LSD could offer a novel approach to pain management, potentially improving the quality of life for individuals suffering from debilitating pain conditions.